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Publications by Author

Publications

 

Ryan Holcomb, Senior Scientist

“Electrode Array Detector for Microchip Capillary Electrophoresis”, Ryan E. Holcomb, James R. Kraly, and Charles S. Henry, Analyst 2009, 134: 486-492.

“Microfluidic Applications in Metabolomics and Metabolic Profiling”, James R. Kraly, Ryan E. Holcomb, Qian Guan, and Charles S. Henry, Analytica Chim. Acta 2009, 653: 23-35.

“Culturing and Investigation of Stress-Induced Lipid Accumulation in Microalgae using a Microfluidic Device”, Ryan E. Holcomb, Lucas J. Mason, Kenneth F. Reardon, Donald M. Cropek, and Charles S. Henry, Analytical Bioanalytical Chem. 2011, 400: 245-253.

“Review of Orthogonal Methods to Size Exclusion Chromatography (SEC) for Quantitation and Characterization of Protein Aggregates”, Ryan R. Manning, Ryan E. Holcomb, Glenn A. Wilson, Charles S. Henry, and Mark Cornell Manning, BioPharm Intl. 2014, 27(11): 32+.

“Role of Buffers in Protein Formulations”, Teddy J. Zbacnik, Ryan E. Holcomb, Derrick S. Katayama, Brian M. Murphy, Robert W. Payne, Richard C. Coccaro, Gabriel J. Evans, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2017, 106: 713-733.

Derrick Katayama, Principal Scientist

“Role of Buffer in Protein Formulation”, T.J. Zbacnik, R.E. Holcomb, D.S. Katayama, B.M. Murphy, R.W. Payne, R.C. Coccaro, G.J. Evans, J.E. Matsuura, C.S. Henry, and M.C.Manning, J. Pharm. Sci. 2017, 106(3):713-733.

“Simultaneous High-Throughput Conformational and Colloidal Stability Screening Using a Fluorescent Molecular Rotor Dye, 4-(4-(Dimethylamino)styryl)-N-Methylpyridinium Iodide (DASPMI)”,  J.J. Wong, S.K. Wright, I. Ghozalli, R. Mehra, K. Furuya, and Derrick S. Katayama, J. Biomol. Screen. 2016, 21(8): 842-850.

“Stability of Protein Pharmaceuticals: An Update”, Mark Cornell Manning, Danny K. Chou, Brian M. Murphy, Robert W. Payne, and Derrick S. Katayama. Pharmaceutical Research 2010, 27(4): 544-575.

“Mixing Properties of Lyophilized Protein Systems: A Spectroscopic and Calorimetric Study”, Derrick S. Katayama, John F. Carpenter, Theodore W. Randolph, Kevin P. Menard, and Mark Cornell Manning, J. Pharm. Sci. 2009, 98(9): 2954-2969.

“Characterization of Amorphous Solids With Weak Glass Transitions with High Ramp Rate Differential Scanning Calorimetry”, Derrick S. Katayama, John F. Carpenter, Mark Cornell Manning, Theodore W. Randolph, DorotaPietkiewicz, Bryan W. Bilyeu, Peter Setlow, and Kevin P. Menard, ,J. Pharm. Sci. 2008, 97(2):1013-1024.

“Solution Behavior Of A Novel Biopharmaceutical Drug Candidate: A Gonadotropin-Toxin Conjugate”, Derrick S. Katayama, Paul Jarosz, and Mark Cornell Manning, Drug Development and Industrial Pharmacy 2006, 32(10):1175-84.

“Temperature dependence of benzyl alcohol- and 8-anilinonaphthalene-1-sulfonate-induced aggregation of recombinant human interleukin-1 receptor antagonist”, Shouvik Roy, Derrick Katayama, Aichun Dong, Bruce A. Kerwin, Theodore W. Randolph, and John F. Carpenter, Biochemistry 2006, 45(12): 3898-3911.

“Effect Of Buffer Species On The Thermally Induced Aggregation Of Interferon-tau“, Derrick S. Katayama, Rajiv Nayar, Danny K. Chou, Joseph J. Valente, Julianne Cooper, Charles S. Henry, Lorelie Villarete, C.P. Liu,  and Mark Cornell, Manning, J. Pharm. Sci. 2006, 95(6) 1212-1226.

“Solution Behavior Of A Novel Type 1 Interferon, Interferon-tau”, Derrick. S. Katayama, Rajiv Nayar, Danny K. Chou, Jackie Campos, Julianne Cooper, David G. Vander Velde, Lorelie Villarete, C.P. Liu, and Mark Cornell Manning, J. Pharm. Sci. 2005, 94(12) 2703-2715.

“Retrospective Statistical Analysis Of Lyophilized Protein Formulations Of Progenipoietin Using PLS: Determination Of The Critical Parameters For Long-Term Storage Stability”, Derrick S. Katayama, Carol F. Kirchhoff, Carrie M. Elliott, Robert E. Johnson, Jeffry Borgmeyer, Barrett R. Thiele, David L. Zeng, Hong Qi, John D. Ludwig, Mark C. Manning, J. Pharm. Sci. 2004, 93(10): 2609-2623.


Robert Payne, Principal Scientist

“Colloidal Behavior of Proteins: Effects of the Second Virial Coefficient on Solubility, Crystallization, and Aggregation of Proteins in Aqueous Solution”, Joseph J. Valente, Robert W. Payne, Mark Cornell Manning, W. William Wilson and Charles S. Henry, Current Pharm. Biotechnol. 2005, 6: 427-436.

“Second Virial Coefficient Determination of a Therapeutic Peptide by Self-Interaction Chromatography”, Robert W. Payne, Rajiv Nayar, Ralph Tarantino, Sam Del Terzo, John Moschera, Jie Di, David Heilmann, Brian Bray, Mark Cornell Manning, and Charles S. Henry, Biopolymers (Peptide Science) 2006, 84: 527-533.

“Peptide Formulation: Challenges and Strategies”, Robert W. Payne and Mark Cornell Manning, Innov. Pharm. Technol. Spring 2009, 28: 64-68.

Tools to Enhance Membrane Protein Crystallization”, W. William Wilson, Gregg Whited, Robert W. Payne, Charles Henry, David H. Johnson, and Larry DeLucas, Current Topics in Membranes 2009, 63: 151-178.
“Stability of Protein Pharmaceuticals: An Update”, Mark Cornell Manning, Danny K. Chou, Brian M. Murphy, Robert W. Payne, and Derrick S. Katayama, Pharm. Res. 2010, 27: 544-575.

“Prediction of Aggregation Propensity from Primary Sequence Information”, Mark Cornell Manning, Gabriel J. Evans, Cody M. Van Pelt, and Robert W. Payne, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 329-347.

“Protein Stability during Bioprocessing”, Mark Cornell Manning, Gabriel J. Evans, and Robert W. Payne, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 605-624.

“Chemical Instability in Peptide and Protein Pharmaceuticals”, Elizabeth M. Topp, Lei Zhang, Hong Zhao, Robert W. Payne, Gabriel J. Evans, and Mark Cornell Manning, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 41-67.

“Product Development Issues with PEGylated Proteins”, Robert W. Payne, Brian M. Murphy, and Mark Cornell Manning, Pharm. Dev. Technol. 2011, 16: 423-440.

“Structure, Stability, and Mobility of a Lyophilized IgG1 Monoclonal Antibody as Determined by Second Derivative Infrared Spectroscopy”, Brian M. Murphy, Ning Zhang, Robert W. Payne, Janice M. Davis, Ahmad M. Abdul-Fattah, James E. Matsuura, Alan C. Herman and Mark Cornell Manning, J. Pharm. Sci. 2012, 101: 81-91.

“Stability of Lyophilized Sucrose Formulations of an IgG1: Subvisible Particle Formation”, Janice M. Davis, Ning Zhang, Robert W. Payne, Brian M. Murphy, Ahmad M. Abdul-Fattah, James E. Matsuura, Alan C. Herman and Mark Cornell Manning, Pharm. Dev. Technol. 2013, 18: 883-896.

“Structural Characteristics of Short Peptides in Solution”, Satoshi Ohtake, Yoshiko Kita, Robert W. Payne, and Mark Cornell Manning, and Tsutomu Arakawa, Protein Peptide Lett. 2013, 20: 1308-1326.

“Role of Buffers in Protein Formulations”, Teddy J. Zbacnik, Ryan E. Holcomb, Derrick S. Katayama, Brian M. Murphy, Robert W. Payne, Richard C. Coccaro, Gabriel J. Evans, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2017, 106: 713-733.

Gabriel Evans, Project Manager

"Solution Behavior of a-Chymotrypsin Dissolved in Nonpolar Solvents Via Hydrophobic Ion Pairing", Jeffrey D. Meyer, James E. Matsuura, Brent S. Kendrick, Emily S. Evans, Gabriel J. Evans, and Mark C. Manning, Biopolymers 1995, 35, 451-456.

“Prediction of Aggregation Propensity from Primary Sequence Information”, Mark Cornell Manning, Gabriel J. Evans, Cody M. Van Pelt, and Robert W. Payne, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 329-347.

“Protein Stability during Bioprocessing”, Mark Cornell Manning, Gabriel J. Evans, and Robert W. Payne, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 605-624.

“Chemical Instability in Peptide and Protein Pharmaceuticals”, Elizabeth M. Topp, Lei Zhang, Hong Zhao, Robert W. Payne, Gabriel J. Evans, and Mark Cornell Manning, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 41-67.

“Role of Buffers in Protein Formulations”, Teddy J. Zbacnik, Ryan E. Holcomb, Derrick S. Katayama, Brian M. Murphy, Robert W. Payne, Richard C. Coccaro, Gabriel J. Evans, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2017, 106: 713-733.

Mark Manning, Chief Scientific Officer

"Reduction of Metal Carbonyl Compounds Using Alkali Metal Carbides", Mark C. Manning and William C. Trogler, Inorg. Chim. Acta 1981, 50, 247-250.

"Electronic Structure of Transition Metal Cluster Complexes", Mark C. Manning and William C. Trogler, Coord. Chem. Rev. 1981, 38, 89-138.

"Xa Calculations and Spectroscopic Studies of Triruthenium and Triosmium  Dodecacarbonyl", Bernard Delley, Mark C. Manning, Donald E. Ellis, Joseph Berkowitz, and William C. Trogler, Inorg. Chem. 1982, 21, 2247-2253.

"Electronic Absorption Spectra of Tetra-µ-acetatodimolybdenum in Low Temperature Matrices" Mark C. Manning and William C. Trogler, Inorg. Chem. 1982, 21, 2797-2800.

"The Electronic Structure of V(CO)6.  Why It Is Black", Gary F. Holland, Mark C. Manning, Donald E. Ellis, and William C. Trogler, J. Am. Chem. Soc. 1983, 105, 2308-2314.

"Electronic Absorption and Emission Spectra of Complexes Containing Dichromium, Dimolybdenum, and Ditungsten Quadruple Bonds", Mark C. Manning and William C. Trogler, J. Am. Chem. Soc. 1983, 105, 5311-5320.

"Spectroscopic and Theoretical Studies on Binuclear Molybdenum (II) Carboxylates", Mark C. Manning,  Gary F. Holland, Donald E. Ellis, and William C. Trogler, J. Phys. Chem. 1983, 87,  3083-3088.

"Molecular Orbital Calculations on the Oligopeptides Netropsin, Distamycin, and Related Compounds", Mark C. Manning and Robert W. Woody, Biopolymers 1986, 25, 2065-2082.

"Theoretical Determination of the Circular Dichroism of Proteins Containing Closely-Packed Antiparallel β Sheets", Mark C. Manning and Robert W. Woody, Biopolymers 1987, 26, 1731-1752.

"Preparation and Characterization of Palladium(II)- and Platinum(II)-OTeF5 Complexes", Mark R. Colsman, Mark C. Manning, Oren P. Anderson, and Steven H. Strauss, Inorg. Chem. 1987, 26, 3958-3960.

"Synthesis and Reactions of Dinuclear Palladium Complexes Containing Methyls and Hydride on Adjacent Palladium Centers: Reductive Elimination and Carbonylation Reactions", S.J. Young, B. Kellenberger, Joseph H. Reibenspies, S.E. Himmel, M. Manning, O.P. Anderson, and J.K. Stille, J. Am. Chem. Soc. 1988, 110, 5744-5753.

"Circular Dichroism Studies of Distorted α Helices, Twisted β Sheets, and β Turns", Mark C. Manning, Mali Illangasekare, and Robert W. Woody, Biophys. Chem. 1988, 31, 77-86.

"Comparison of the Secondary Structures of Human Class I and Class II MHC Antigens by IR and CD Spectroscopy", Joan C. Gorga, Aichun Dong, Mark C. Manning, Robert W. Woody, Winslow S. Caughey, and Jack L. Strominger, Proc. Natl. Acad. Sci. USA 1989, 86, 2321-2325.

"Contribution of Aromatic Side Chains to the Circular Dichroism of Basic Bovine Pancreatic Trypsin Inhibitor (BPTI): A Theoretical Study", Mark C. Manning and Robert W. Woody, Biochemistry  1989, 28, 8609-8613.

"Stability of Protein Pharmaceuticals", Mark C. Manning, Kamlesh Patel, and Ronald T. Borchardt, Pharmaceutical Res.  1989, 6, 903-918.

“Comparison of the Secondary Structures of Human Class-I and Class-II MHC Antigens by FTIR and CD Spectroscopy”, Joan C. Gorga, Aichun Dong, Mark C. Manning, Robert W. Woody, Winslow S. Caughey, and J.L. Strominger, in Protein Structure and Engineering (NATO Advanced Science Institute Series, Series A, Life Sciences), Volume 183, O. Jardetzky, Ed., Plenum Press, 1989, pp. 355-365.

"Conformation of the Alpha Form of Calcitonin Gene-Related Peptide (CGRP) in Aqueous Solution as Determined by Circular Dichroism Spectroscopy", Mark C. Manning, Biochem. Biophys. Res. Commun. 1989, 160, 388-392.

"Underlying Assumptions in the Estimation of Secondary Structure Content in Proteins by Circular Dichroism Spectroscopy- A Critical Review", Mark C. Manning, J. Pharm. Biomed. Anal.  1989, 7, 1103-1119.

"Theoretical CD Calculations of Polypeptide Helices.  Determination of the Important Electronic and Geometric Factors", Mark C. Manning and Robert W. Woody, Biopolymers  1991, 31, 569-586.

"Protein Chemistry: A Graduate Course in Pharmaceutical Biotechnology at the University of Kansas", Mark C. Manning and James W. Mitchell, Am. J. Pharm. Educ.  1991, 55, 52-55.

"Stability of the Thrombolytic Protein Fibrolase. Effect of Temperature and pH on Activity and Conformation", Denise Pretzer, Brenda S. Schulteis, Christopher D. Smith, David G. Vander Velde, James W. Mitchell, and Mark C. Manning, Pharmaceutical Res.  1991, 8, 1103-1112.

"The Helix-Coil Transition in Heterogenous Peptides with Specific Side Chain Interactions", Paul M. Gans, Pingchiang C. Lyu, Mark C. Manning, Robert W. Woody, and Neville R. Kallenbach, Biopolymers  1991, 31, 1605-1614.

"Protein Structure and Stability Assessment by Circular Dichroism Spectroscopy", Mark C. Manning,  in Biocatalyst Design for Stability and Specificity, Michael E. Himmel and George Georgiou, Eds., ACS Symposium Series 1992, 516, 33-52.

"Pharmaceutical Biotechnology. Protein Stability and Its Enhancement- An Overview", Tim J. Ahern and Mark C. Manning, in Pharmaceutical Biotechnology, Volume 2, Tim J. Ahern and Mark C. Manning, Eds., Plenum Press, New York, 1992, pp. ix-xvii.

"Stability of Protein Pharmaceuticals: Chemical and Physical Pathways of Protein Degradation", Volume 2 of Pharmaceutical Biotechnology, Tim J. Ahern and Mark C. Manning, Editors, Plenum Press, New York, 1992.

"Stability of Protein Pharmaceuticals: in vivo Pathways of Degradation and Strategies for Protein Stabilization", Volume 3 of Pharmaceutical Biotechnology, Tim J. Ahern and Mark C. Manning, Editors, Plenum Press, New York, 1992.

"Effect of Zinc Binding on the Structure and Stability of Fibrolase, a Fibrinolytic Protein from Snake Venom", Denise Pretzer, Brenda S. Schulteis, Christopher D. Smith, David G. Vander Velde, James W. Mitchell, and Mark C. Manning, Pharmaceutical Res. 1992, 9, 870-877.

"The Use of Computer Aided Modeling to Understand Peptide Transport", R.A. Gray, D.G. Vander Velde, R.T. Borchardt, C.J. Burke, C.R. Middaugh, and M.C. Manning,  Chemical Design Automation News  1992, 7, 1, 36-39, 41.

"Structure and Stability of Insulin Dissolved in 1-Octanol", James Matsuura, Michael E. Powers, Mark C. Manning, and Eli Shefter, J. Am. Chem. Soc. 1993, 115, 1261-1264.

"Fibrolase, a Fibrinolytic Protein from Snake Venom", Denise Pretzer, Brenda Schulteis, Chris Smith, David G. Vander Velde, James W. Mitchell, and Mark C. Manning, in Pharmaceutical Biotechnology, Volume 5, Y. J. Wang and R. Pearlman, Eds., Plenum Press, 1993, 287-314.

"Conformation of Human Calcitonin Gene-Related Peptide(8-37) in Aqueous Solution as Determined by Circular Dichroism Spectroscopy", James Matsuura and Mark C. Manning, J. Pharm. Biomed. Anal.  1993, 11, 89-93.

"Enhanced Solubility of Proteins and Peptides in Nonpolar Solvents Through Hydrophobic Ion Pairing", Michael E. Powers, James Matsuura, James Brassell, Mark C. Manning, and Eli Shefter, Biopolymers  1993, 33, 927-932.

"Thermal Stability of Low Molecular Weight Urokinase During Heat Treatment. I. Effects of Protein Concentration, pH and Ionic Strength", William R. Porter, Harold Staack, Karol Brandt, and Mark C. Manning, Thrombosis Research 1993, 71, 265-279.

"Circular Dichroism in the Analysis of Protein Structure", John F. Towell, III and Mark C. Manning, in Analytical Applications of Circular Dichroism, N. Purdie and H.G. Brittain, Eds., Elsevier, 1994, 175-205.

"Delta-Sleep Inducing Peptide: Solution Conformational Studies of a Membrane-Permeable Peptide", Ronda A. Gray, David G. Vander Velde, Carl J. Burke, Mark C. Manning, Gautam Sanyal, C. Russell Middaugh, and Ronald T. Borchardt, Biochemistry 1994, 33, 1323-1331.

"Solution Behavior of Leuprolide Acetate, a LHRH Agonist, as Determined by Circular Dichroism Spectroscopy", Michael E. Powers, Akwete Adjei, Mou-Ying Fu Lu, and Mark C. Manning, Int. J. Pharm. 1994, 108, 49-56.

"Thermal Stability of Low Molecular Weight Urokinase during Heat Treatment. II. Effects of Polymeric Additives", Michael Vrkljan, Michael E. Powers, Thomas M. Foster, Jack Henkin, William R. Porter, John F. Carpenter, and Mark C. Manning, Pharmaceutical Res. 1994, 11, 1004-1008.

"Selective Precipitation of Interleukin-4 Using Hydrophobic Ion Pairing: A Method for Improved Analysis of Proteins Formulated with Large Excesses of Human Serum Albumin", Jeffrey D. Meyer, James E. Matsuura, James A. Ruth, Eli Shefter, Suman T. Patel, James Bausch, Eugene McGonigle, and Mark C. Manning, Pharmaceutical Res. 1994, 11, 1492-1495.

"Heat-Induced Gelation of Beta-Lactoglobulin: A Study of the Secondary and Tertiary Structure as Followed by Circular Dichroism Spectroscopy", James E. Matsuura and Mark C. Manning, J. Agric. Food Chem. 1994, 42, 1650-1656.

"Two-, Three-, and Four-Dimensional Nuclear Magnetic Resonance Spectroscopy of Protein Pharmaceuticals", David G. Vander Velde, James Matsuura, and Mark C. Manning, in Pharmaceutical Biotechnology, Volume 7, James Herron, Wim Jiskoot, and Daan J.A. Crommelin, Eds., Plenum Press, New York, 1995, 179-218.

"Approaches for Increasing the Solution Stability of Proteins", Mark C. Manning, James E. Matsuura, Brent S. Kendrick, Jeffrey D. Meyer, Jonathon J. Dormish, Michael Vrkljan, James R. Ruth, John F. Carpenter, and Eli Shefter, Biotechnol. Bioeng. 1995, 48, 506-512.

"Solution Behavior of a-Chymotrypsin Dissolved in Nonpolar Solvents Via Hydrophobic Ion Pairing", Jeffrey D. Meyer, James E. Matsuura, Brent S. Kendrick, Emily S. Evans, Gabriel J. Evans, and Mark C. Manning, Biopolymers 1995, 35, 451-456.

"Sequence Analysis of Fibrolase, a Fibrinolytic Metalloproteinase from Agkistrodon contortrix contortrix", Mark C. Manning, Toxicon 1995, 33, 1189-1200.

"Infrared and Circular Dichroism Spectroscopic Characterization of Structural Differences in b-Lactoglobulin Genetic Variants", Aichun Dong, James Matsuura, S. Dean Allison, Eric Chrisman, Mark C. Manning, and John F. Carpenter, Biochemistry 1996, 35, 1450-1457.

"Quantitation of Area of Overlap between Second Derivative Amide I Infrared Spectra to Determine Structural Similarity of a Protein in Different States", Brent S. Kendrick, Aichun Dong, S. Dean Allison, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 1996, 85, 155-158.

"Generation of Soluble and Active Subtilisin in Organic Solvents Via Hydrophobic Ion Pairing", Jeffrey D. Meyer, Brent S. Kendrick, James E. Matsuura, James A. Ruth, Philip N. Bryan, and Mark C. Manning, Int. J. Peptide Protein Res. 1996, 47, 177-181.

"Thermal Stability of Low Molecular Weight Urokinase during Heat Treatment. III. Effects of Salts, Sugars, and Additional Purification", Thomas M. Foster, Jonathon J. Dormish, Uday Narahari, Jeffrey D. Meyer, Michael Vrkljan, Jack Henkin, William R. Porter, John F. Carpenter, and Mark C. Manning, Int. J. Pharm. 1996, 134, 193-202.

"Effect of Secondary Structure on the Activity of Enzymes Suspended in Nonaqueous Solvents", Aichun Dong, Jeffrey D. Meyer, Brent S. Kendrick, Mark C. Manning, and John F. Carpenter, Arch. Biochem. Biophys. 1996, 334, 406-414.

"Dual Modes of Activation of Mitogen-Activated Protein Kinase Kinase 1 as Revealed by Kinetic Analysis and Mutagenesis", Sam Mansour, Julian M. Candia, James E. Matsuura, Mark C. Manning, and Natalie G. Ahn, Biochemistry 1996, 35, 15529-15536.

"Controlled Release of Ionic Pharmaceuticals from Poly (L-lactide) Microspheres Produced by Precipitation with a Compressed Antisolvent", Richard F. Falk, Theodore W. Randolph, Jeffrey D. Meyer, R. Michael Kelly, and Mark C. Manning, J. Controlled Rel. 1997, 44, 77-85.

"Investigation of the aT244M Mutation in the Alpha Subunit of Paracoccus dentrificans Electron Transfer Flavoprotein", Kurt J. Griffin, Timothy M. Dwyer, Mark C. Manning, Jeffrey D. Meyer, John F. Carpenter, and Frank E. Frerman, Biochemistry 1997, 36, 4194-4202.

"Secondary Structure of Human Cystathione b-Synthase in Aqueous Solution: Effect of Ligands and Proteolytic Truncation", Aichun Dong, Vladamir Kery, James Matsuura, Mark C. Manning, Jan P. Kraus, and John F. Carpenter, Arch. Biochem. Biophys. 1997, 344, 125-132.

"Drug Delivery Matrix Containing Native Protein Precipitates Suspended in a Poloxamer 407 Gel", Lewis P. Stratton, Aichun Dong, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci.1997, 86, 1006-1010.

"Structure-Activity Studies on Position 14 of Human-a-Calcitonin Gene-Related Peptide (h-a-CGRP)", Jianzhong Li, James E. Matsuura, Thomas E. Adrian, Mark C. Manning, and D. David Smith, J. Med. Chem. 1997, 40, 3071-3076.

"Preferential Exclusion of Sucrose from Recombinant Human Interleukin-1 Receptor Antagonist: Role of Restricted Conformational Mobility and Compaction of Native State", Brent S. Kendrick, Byeong S. Chang, Tsutomu Arakawa, Ted Randolph, Mark C. Manning, and John F. Carpenter, Proc. Natl. Acad. Sci. USA 1997, 94, 11917-11922.

"Spectroscopic Study of Secondary Structure and Thermal Denaturation of Recombinant Human Factor XIII in Aqueous Solution", Aichun Dong, Lotte Krielgaard, Brent S. Kendrick, James Matsuura, Mark C. Manning, and John F. Carpenter, Arch. Biochem. Biophys. 1997, 347, 213-220.

"Use of Circular Dichroism Spectroscopy in Determining the Conformation of a Monoclonal Antibody Prior to its Incorporation in an Immunoliposome" Ka-yun Ng, Limin Zhao, Jeffrey D. Meyer, Lana Grauer-Kittman, and Mark C. Manning, J. Pharm. Biomed. Anal. 1997, 16, 507-513.

"Hydrophobic Ion Pairing of Subtilisin BPN' Results in Structural Stabilization and Increased Activity in Isooctane", Brent S. Kendrick, Jeffrey D. Meyer, James E. Matsuura, John F. Carpenter, and Mark C. Manning, Arch. Biochem. Biophys. 1997, 347, 113-118.

"Hydrophobic Ion Pairing: Altering the Solubility of Biomolecules", Jeffrey D. Meyer and Mark C. Manning, Pharmaceutical Res. 1998, 15, 188-193.

"The Phage Lambda Terminase Enzyme. 1. Reconstitution of the Holoenzyme from the Individual Subunits Enhances the Thermal Stability of the Small Subunit", Jeffrey D. Meyer, A. Hanagan, Mark C. Manning, and Carlos Enrique Catalano, Int. J. Biol. Macromol. 1998, 23, 27-36.

"The Phage Lambda Terminase Enzyme. 2. Refolding of the gpNu1 Subunit from the Detergent-Denatured and Guanidinium Hydrochloride-Denatured State Yields Different Oligomerization States and Altered Protein Stabilities", Jeffrey D. Meyer, Adrienne Hanagan, Mark C. Manning, and Carlos Enrique Catalano, Int. J. Biol. Macromol. 1998, 23, 37-48.

"Alveolar Macrophage Cell Line is Not Activated by Exposure to Polymeric Microspheres", Ka-yun Ng, Kathleen A. Stringer,  Zoe Cohen, Robert Serravo, Bin Tian, Jeffrey D. Meyer, Richard Falk, Theodore W. Randolph, Mark C. Manning, and David C. Thompson, Int. J. Pharm. 1998, 170, 41-50.

"Preparation and In Vitro Characterization of Gentamycin-Impregnated Biodegradable Beads Suitable for Treatment of Osteomyelitis", Jeffrey D. Meyer, Richard F. Falk, R. Michael Kelly, Jesse E. Shively, Steven J. Withrow, William S. Dernell, Theodore W. Randolph, and Mark C. Manning, J. Pharm. Sci. 1998, 87, 1149-1154.

"Aggregation of Recombinant Human Interferon-gamma: Kinetics and Structural Transitions", Brent S. Kendrick, Jeffrey L. Cleland, Xanthe Lam, Tue Nguyen, Theodore W. Randolph, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 1998, 87, 1069-1076.

"Intermolecular b-Sheet Results from Trifluoroethanol-Induced Non-Native a-Helical Structure in b-Sheet Predominant Proteins: Infrared and Circular Dichroism Spectroscopic Study", Aichun Dong, James E. Matsuura, Mark C. Manning, and John F. Carpenter, Arch. Biochem. Biophys. 1998, 355, 275-281.

"Effects of Drying Methods and Additives on Structure and Function of Actin: Mechanisms of Dehydration-Induced Damage and Its Inhibition", S. Dean Allison, Theodore W. Randolph, Mark C. Manning, Kim Middleton, Ashley Davis, and John F. Carpenter, Arch. Biochem. Biophys. 1998, 358, 171-181.

"Secondary Structure of Antifreeze Proteins from Overwintering Larvae of the Beetle Dendroides canadensis", Ning Li, Brent S. Kendrick, Mark C. Manning, John F. Carpenter, and John G. Duman, Arch Biochem. Biophys. 1998, 360, 25-32.

"Effect of Tween 20 on Freeze-Thawing and Agitation-Induced Aggregation of Recombinant Human Factor XIII", Lotte Kreilgaard, LaToya S. Jones, Theodore W. Randolph, Sven Frokjaer, James M. Flink, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 1998, 87, 1597-1603.

"Tween Protects Recombinant Human Growth Hormone against Agitation-Induced Damage via Hydrophobic Interactions", Narendra B. Bam, Jeffrey L. Cleland, Mark C. Manning, John F. Carpenter, Robert F. Kelley, and Theordore W. Randolph, J. Pharm. Sci. 1998, 87, 1554-1559.

"Cloning, Expression and Characterization of a DNA Binding Domain of gpNu1, a Phage Lambda DNA Packaging Protein", Qin Yang, Tonny de Beer, Liping Woods, Jeffrey D. Meyer, Mark C. Manning, Michael Overduin, and Carlos Enrique Catalano, Biochemistry 1999, 38, 465-477.

"Binding of Pyridoxal 5'-Phosphate to the Heme Protein Cystathione b-Synthase", Vladamir Kery, Loelle Poneleit, Jeffrey D. Meyer, Mark C. Manning, and Jan P. Kraus, Biochemistry 1999, 38, 2716-2724.

"Inhibition of Stress-Induced Aggregation in Protein Therapeutics", John F. Carpenter, Brent S. Kendrick, Byeong S. Chang, Mark C. Manning, and Theodore W. Randolph, in Methods in Enzymology, R. Wetzel, ed., Academic Press 1999, 309, 236-255.

"In Vitro Release Kinetics of Gentamycin Sulfate from a Hyaluronate Gel Delivery System for the Treatment of Peripheral Vestibular Disease", R. Michael Kelly, Jeffrey D. Meyer, James E. Matsuura, Eli Shefter, Michael J. Hart, Daniel C. Malone, and Mark C. Manning, Drug Dev. Ind. Pharm. 1999, 25, 15-20.

"Tyrosine, Phenylalanine, and Disulfide Contributions to the Circular Dichroism of Proteins: CD Spectra of Wild Type and Mutant Bovine Pancreatic Trypsin Inhibitor", Narasimha Sreerama, Mark C. Manning, Michael E. Powers, Jian-Xin Zhang, David P. Goldenberg, and Robert W. Woody, Biochemistry 1999, 38, 10814-10822.

"Domain Structure of gpNu1, a Phage Lambda DNA Packaging Protein: Identification of Self-Association and gpA-Interactive Domains", Qin Yang, Nancy Berton, Mark C. Manning, and Carlos E. Catalano, Biochemistry 1999, 38, 14238-14247.

"Optimizing Storage Stability of Lyophilized Actin with Dextran/Disaccharide Mixtures", S.D. Allison, A. Williams, K. Middleton, T.W. Randolph, M.C. Manning and J.F. Carpenter, J. Pharm. Sci. 2000, 89, 199-214.

"Long Chain Arginine Esters: A New Class of Biocompatible Cationic Detergents", David J. Claffey, Jeffrey D. Meyer, Robert Beauvais, Tessa Brandt, Eli Shefter, David J. Kroll, James A. Ruth, and Mark C. Manning, Biochem. Cell Biol. 2000, 78, 59-65.

"Thermodynamic Modulation of Light Chain Amyloid Fibril Formation", Yong-sung Kim, Jonathan S. Wall, Jeffrey Meyer, Charles Murphy, Theodore W. Randolph, Mark C. Manning, and John F. Carpenter, J. Biol. Chem. 2000, 275, 1570-1573.

"Intracavitary Slow Release Paclitaxel Polymer in a Rodent Model of Mammary Carcinoma", V.S. Bregazzi, W.S. Dernell, D.J. Huber, R. Schochet, M. Lafferty, G.K. Oglivie, S.J. Withrow, B.E. Powers, and M. Manning, J. Bioactive Compatible Polym. 2000, 15, 85-88.

"Stability of Human Serum Albumin during Bioprocessing. Denaturation and Aggregation during Processing of Albumin Paste", Jen-Jen Lin, Jeffrey D. Meyer, John F. Carpenter, and Mark C. Manning, Pharmaceutical Res. 2000, 17, 391-396.

"Effect of Zinc-Binding and Precipitation on Structures of Recombinant Human Growth Hormone and Nerve Growth Factor", Tzung-Horng Yang, Jeffrey L. Cleland, Jeffrey D. Meyer, LaToya S. Jones, Theodore W. Randolph, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 2000, 89, 1480-1485.

"Comparative FT-IR and CD Spectroscopic Analysis of a1-Proteinase Inhibitor and Ovalbumin in Aqueous Solution", Aichun Dong, Jeffrey D. Meyer, Mark C. Manning, Jerry L. Brown, and John F. Carpenter, Arch. Biochem. Biophys. 2000, 383, 148-155.

“Counteracting Effects of Renal Solutes in Amyloid Fibril Formation by Immunoglobulin Light Chains”, Yong-sung Kim, Stephen P. Cape, Eva Chi, Rosemarie Raffen, Priscilla Wilkins-Stevens, Fred J. Stevens, Mark C. Manning, Theodore W. Randolph, Alan Solomon, and John F. Carpenter, J. Biol. Chem. 2001, 276, 1626-1633.

"In Vivo Evaluation of Gentamicin-Impregnated Polylactic Acid Beads Implanted in Sheep", W.S. Dernell, S.J. Withrow, M.C. Manning, C.A. Kuntz, R. Dewell, F.B. Garry, B.E. Powers, J.E. Shively, R.F. Falk, and T.W. Randolph, J. Bioactive Compatible Polym.  2001, 16, 119-135.

"In Vivo Evaluation of Antibiotic-Impregnated Beads in a Rat Osteomyelitis Model", W.S. Dernell, C. Gentry-Weeks, M. C. Manning, B.E. Powers, M. Lafferty, C.A. Kuntz, J.E. Shively, R.F. Falk, J.D. Meyer, T.W. Randolph, and S.J. Withrow, J. Bioactive Compatible Polym. 2001, 16, 235-252.

“The Effect of Including Tween 20 and/or Sucrose in the Lyophilization and Reconstitution Medium of a Lyophilized Antibody”, LaToya S. Jones, Theodore W. Randolph, Ulrich Kohnert, Apollon Papadimitriou, Gerhard Winter, Marie-Luise Hagmann, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 2001, 90, 1466-1477.

“Controlling Deamidation Rates in a Model Peptide: Effects of Temperature, Peptide Concentration, and Additives”, Lewis P. Stratton, R. Michael Kelly, Jared Rowe, Jesse E. Shively, D. David Smith, John F. Carpenter, and Mark C. Manning, J. Pharm. Sci. 2001, 90, 2141-2148.

“High Throughput Drug Development: Meeting the Coming Challenges”, Rajiv Nayar and Mark C. Manning, BioPharm Feb. 2002, 25-32.

"Rational Design of Stable Protein Formulations: Theory and Practice", Volume 13 of Pharmaceutical Biotechnology, John F. Carpenter and Mark C. Manning, Editors, Plenum Press, New York, 2002.

"High Throughput Formulation: New Strategies for Developing Stable Protein Formulations", Rajiv Nayar and Mark C. Manning, in Pharmaceutical Biotechnology, Volume 13, John F. Carpenter and Mark C. Manning, Eds., Kluwer Academic/Plenum Press, New York, 2002, 177-198 .

"Effect of Conformation on the Chemical Stability of Polypeptides", Jeffrey D. Meyer, Bert Ho, and Mark C. Manning, in Pharmaceutical Biotechnology, Volume 13, John F. Carpenter and Mark C. Manning, Eds., Kluwer Academic/Plenum Press, New York, 2002, 85-107.

“Encapsulating DNA within Biodegradable Polymeric Microspheres”, Corinne S. Lengsfeld, Mark C. Manning, and Theodore W. Randolph, Curr. Pharm. Biotechnol. 2002, 3, 227-235.

"Evaluation of Cisplatin in Combination with a Biological Response Modifier in a Murine Mammary Carcinoma Model", Emanuela, Morello, William S. Dernell, Charles A. Kuntz, Mary Lafferty, Ann Nelson, John H. Brekke, Craig H. Mallinckrodt, Stephen J. Withrow, and Mark C. Manning, Cancer Investigations 2002, 20, 480-489.

“Ion Pairing of Isoniazid Using a Prodrug Approach”, Huiyu Zhou, Corinne S. Lengsfeld, David J. Claffey, James A. Ruth, Brooks A. Hybertson, Theodore W. Randolph, Ka-yun Ng, and Mark C. Manning, J. Pharm. Sci. 2002, 91, 1502-1511.

“Long-Term Storage of Proteins”, John F. Carpenter, Mark C. Manning, and Theodore W. Randolph, Current Protocols in Protein Science 2002, 4.6.1-4.6.6.

“The Stability Factor: Importance in Formulation Development”, Rajesh Krishnamurthy and Mark C. Manning, Curr. Pharm. Biotechnol. 2002, 3, 361-371.

“Aggregation of Granulocyte Colony Stimulating Factor under Physiological Conditions: Characterization and Thermodynamic Inhibition”, Sampathkumar Krishnan, Eva Y. Chi, Jonathan N. Webb, Byeong S. Chang, Daxian Shan, Merrill Goldenberg, Mark C. Manning, Theodore W. Randolph, and John F. Carpenter, Biochemistry 2002, 41, 6422-6431.

“Dissolution and Partitioning Behavior of Hydrophobic Ion Paired Complexes”, Douglas Pitera, Corinne S. Lengsfeld, Mark C. Manning, and Theodore W. Randolph, Pharm. Res. 2002, 19, 1572-1576.

"Characterization of the Solution Conformations of Leuprolide Acetate", Jeffrey D. Meyer, Mark C. Manning, and David G. Vander Velde, J. Peptide Res.  2002, 60, 159-168.

“Lipid Unsaturation Determines the Interaction of AFP Type I with Model Membranes during Thermotropic Phase Transitions”, Melanie M. Tomczak, László Vigh, Jeffrey D. Meyer, Mark C. Manning, Dirk. K. Hincha, and John H. Crowe, Cryobiology 2002, 45, 135-142.

“Congo Red Populates Partially Unfolded States of an Amyloidogenic Protein to Enhance Aggregation and Amyloid Fibril Formation”, Yong-Sung Kim, Theodore W. Randolph, Mark C. Manning, Fred J. Stevens, and John F. Carpenter, J. Biol. Chem. 2003, 278, 10842-10850.

“The Use of Fluorescence Resonance Energy Transfer to Monitor Dynamic Changes of Lipid-DNA Interactions during Lipoplex Formation”, Ye Zhang, William Garzon-Rodriguez, Mark C. Manning, and Thomas J. Anchordoquy, Biochim. Biophys. Acta 2003, 1614, 182-192.

“High-Throughput Formulation of Biopharmaceutical Products in the Postgenomic Age”, Shu Jun Bai, Derrick S. Katayama, Danny K.C. Chou, Thomas J. Anchordoquy, Rajiv Nayar, and Mark C. Manning, Genomic/Proteomic Technology, October 2003, 28F-28H.

“Effects of Sucrose on Conformational Equilibria and Fluctuations within the Native State Ensemble of Proteins”, Yong-sung Kim, LaToya S. Jones, Aichun Dong, Brent S. Kendrick, Byeong S. Chang, Mark C. Manning, Theodore W. Randolph and John F. Carpenter, Protein Sci. 2003, 12, 1252-1261.

In vitro and in vivo Evaluation of the Effects of PLA Microparticle Crystallinity on Cellular Response”, Danielle L. Biggs, Corinne S. Lengsfeld, Brooks M. Hybertson, Ka-yun Ng, Mark C. Manning, and Theodore W. Randolph, J. Controlled Rel.2003, 92: 147-161.

“Effects of KBr Disk Formation on the Infrared Spectra of Model Proteins”, Jeffrey D. Meyer, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 2004, 93, 496-506.

“Infrared Spectroscopic Studies of Protein Formulations Containing Glycine”, Jeffrey D. Meyer, Shu Jun Bai, Meena Rani, Raj Suryanarayanan, Rajiv Nayar, John F. Carpenter, and Mark C. Manning, J. Pharm. Sci. 2004, 93: 1359-1366.

“Improved Potency of Cisplatin by Hydrophobic Ion Pairing”, Lixin Feng, Alexandra De Lille, Vicky J. Jameson, Leia Smith, William S. Dernell, and Mark C. Manning, Cancer Chemother. Pharmacol. 2004, 54: 441-448.

“Quantification of Glycine Crystallinity by Near-Infrared Spectroscopy”, Shu Jun Bai, Meena Rani, Raj Suryanarayanan, John F. Carpenter, Rajiv Nayar, and Mark C. Manning, J. Pharm. Sci. 2004, 93: 2439-2447.

“Retrospective Statistical Analysis of Lyophilized Formulations of Progenipoietin using PLS. Determination of the Critical Parameters for Long-term Storage Stability”, Derrick S. Katayama, Carol F. Kirchhoff, Carrie M. Elliott, Robert E. Johnson, Jeffry Borgmeyer, Barrett R. Thiele, David L. Zeng, Hong Qi, John D. Ludwig, and Mark C. Manning, J. Pharm. Sci. 2004, 93: 2609-2623.

“Degradation Kinetics of High Molecular Weight Poly(L-lactide) Microspheres and Release Mechanism of Lipid-DNA Complexes”, Mayank M. Patel, Micelle G. Zeles, Mark C. Manning, Theodore W. Randolph, and Thomas J. Anchordoquy, J. Pharm. Sci. 2004, 93: 2573-2584.

“Mechanism for Benzyl Alcohol-Induced Aggregation of Recombinant Interleukin-1 Receptor Antagonist in Aqueous Solution”, Ye Zhang, Shouvik Roy, LaToya S. Jones, Sampathkumar Krishnan, Bruce A. Kerwin, Byeong S. Chang, Mark C. Manning, Theodore W. Randolph, and John F. Carpenter, J. Pharm. Sci. 2004, 93: 3076-3089.

“Protease Autolysis in Heavy-Duty Detergent Formulations: Effects of Thermodynamic Stabilizers and Protease Inhibitors” Michael R. Stoner, Douglas A. Dale, Peter J. Gualfetti, Todd Becker, Mark C. Manning, John F. Carpenter, and Theodore W. Randolph, Enzyme Microb. Technol. 2004, 34: 114-125.

“Self-Interaction Chromatography for Screening”, Charles S. Henry, Robert W. Payne, Joseph J. Valente, and Mark Cornell Manning, Genetic Eng. News 2005, 25 (8): 62-63.

“Heterogeneous Nucleation-Controlled Particulate Formation of Recombinant Human Platelet-Activating Factor Acetylhydrolase in Pharmaceutical Formulation”, Eva Y. Chi, Joachim Weickmann, John F. Carpenter, Mark C. Manning, and Theodore W. Randolph, J. Pharm. Sci. 2005, 94: 256-274.

“Effects of Tween 20 and Tween 80 on the Stability of Albutropin during Agitation”, Danny K. Chou, Rajesh Krishnamurthy, Theodore W. Randolph, John F. Carpenter, and Mark Cornell Manning, J. Pharm. Sci. 2005, 94: 1368-1381.

“Use of Infrared Spectroscopy to Monitor Protein Structure and Stability”, Mark Cornell Manning, Expert Rev. Proteomics 2005, 2 (5): 731-743.

“Colloidal Behavior of Proteins: Effects of the Second Virial Coefficient on Solubility, Crystallization, and Aggregation of Proteins in Aqueous Solution”, Joseph J. Valente, Robert W. Payne, Mark Cornell Manning, W. William Wilson and Charles S. Henry, Current Pharm. Biotechnol. 2005, 6: 427-436.

“Noninvasive Determination of Protein Conformation in the Solid State Using Near Infrared (NIR) Spectroscopy”, Shujun Bai, Rajiv Nayar, John F. Carpenter, and Mark Cornell Manning, J. Pharm. Sci. 2005, 94: 2030-2038.

“Solution Behavior of a Novel Type 1 Interferon, Interferon-tau“, Derrick S. Katayama, Rajiv Nayar, Danny K. Chou, Jackie Campos, Julianne Cooper, David G. Vander Velde, Lorelie Villarete, C.P. Liu, and Mark Cornell Manning, J. Pharm. Sci. 2005, 94: 2703-2713.

“Feasibility of Tissue Plasminogen Activator Formulated for Pulmonary Delivery”, John S. Dunn, Rajiv Nayar, Jackie Campos, Brooks M. Hybertson, Y. Zhou, Mark Cornell Manning, John E. Repine, and Kathleen A. Stringer, Pharm. Res. 2005, 22: 1700-1707.
“Microparticle-based Lung Delivery of INH Decreases INH Metabolism and Targets Alveolar Macrophages”, Huiyu Zhou, Yangling Zhang, Danielle L. Biggs, Mark C. Manning, Theodore W. Randolph, Uwe Christians, Brooks M. Hybertson, and Ka-yun Ng, J. Controlled Rel. 2005, 107: 288-299.

“Towards the Systematic Use of Virial Coefficient Studies for Evaluating Cosolvent-Induced Stabilization and Solubilization of Proteins”, Joseph J. Valente, Kusum Verma, Mark Cornell Manning, W. William Wilson, and Charles S. Henry, Biophys. J. 2005, 89: 4211-4218.

 “Effects of Buffer Species on the Thermally Induced Aggregation of Interferon-tau”, Derrick S. Katayama, Rajiv Nayar, Danny K. Chou, Joseph J. Valente, Julianne Cooper, Charles S. Henry, David G. Vander Velde, Lorelie Villarete, C.P. Liu, and Mark Cornell Manning, J. Pharm. Sci. 2006, 95: 1212-1226.

“Solution Behavior of a Novel Biopharmaceutical Drug Candidate: A Gonadotropin-Toxin Conjugate”, Derrick S. Katayama, Paul Jarosz, and Mark Cornell Manning, Drug Dev. Ind. Pharm. 2006, 32: 1175-1184.

“Second Virial Coefficient Determination of a Therapeutic Peptide by Self-Interaction Chromatography”, Robert W. Payne, Rajiv Nayar, Ralph Tarantino, Sam Del Terzo, John Moschera, Jie Di, David Heilmann, Brian Bray, Mark Cornell Manning, and Charles S. Henry, Biopolymers (Peptide Science) 2006, 84: 527-533.

“Characterization of Amorphous Solids with Weak Glass Transitions Using High Ramp Rate Differential Scanning Calorimetry”, Derrick S. Katayama, John F. Carpenter, Mark Cornell Manning, Theodore W. Randolph, Peter Setlow, and Kevin P. Menard, J. Pharm. Sci. 2008, 97: 1013-1024.

“Mixing Properties of Lyophilized Protein Systems: A Spectroscopic and Calorimetric Study”, Derrick S. Katayama, John F. Carpenter, Kevin P. Menard, Mark Cornell Manning, and Theodore W. Randolph, J. Pharm. Sci. 2009, 98: 2954-2969.

“Stability of Human Serum Albumin during Bioprocessing. Aggregation during Terminal Heat Treatment”, Jen-Jen Lin, Jeffrey D. Meyer, John F. Carpenter, and Mark Cornell Manning, Intl. J. Biol. Macromol. 2009, 45: 91-96.

“Impact of Bulking Agents on the Stability of a Lyophilized Monoclonal Antibody”, Jeffrey D. Meyer, Rajiv Nayar, and Mark Cornell Manning, Eur. J. Pharm. Sci. 2009, 38: 29-38.

“Ability of Two All Natural Products, Nootkatone and Carvacrol, to Supress Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) in a Lyme Disease Endemic Area of New Jersey”, Marc C. Dolan, Robert A. Jordan, Terry L. Schulze, Christopher J. Schulze, Mark Cornell Manning, Daniel Ruffolo, Jason P. Schmidt, Joseph Piesman, and Joseph J. Karchesy, J. Econ. Entomol. 2009, 102: 2316-2324.

“Peptide Formulation: Challenges and Strategies”, Robert W. Payne and Mark Cornell Manning, Innov. Pharm. Technol. Spring 2009, 28: 64-68.

“Multivariate Analysis of the Sequence Dependence of Asparagine Deamidation Rates in Peptides”, Andrew A. Kosky, Vasumathi Dharmavaram, Gayathri Ratnaswamy, and Mark Cornell Manning, Pharmaceutical Res. 2009, 26: 2417-2428.

“Stability of Protein Pharmaceuticals: An Update”, Mark Cornell Manning, Danny K. Chou, Brian M. Murphy, Robert W. Payne, and Derrick S. Katayama, Pharm. Res. 2010, 27: 544-575.

“Prediction of Aggregation Propensity from Primary Sequence Information”, Mark Cornell Manning, Gabriel J. Evans, Cody M. Van Pelt, and Robert W. Payne, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 329-347.

“Protein Stability during Bioprocessing”, Mark Cornell Manning, Gabriel J. Evans, and Robert W. Payne, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 605-624.

“Chemical Instability in Peptide and Protein Pharmaceuticals”, Elizabeth M. Topp, Lei Zhang, Hong Zhao, Robert W. Payne, Gabriel J. Evans, and Mark Cornell Manning, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 41-67.

“Aggregation of Recombinant Human Botulinum Protein Antigen Serotype C in Varying Solution Conditions: Implications of Conformational Stability on Aggregation Kinetics”, Shujun Bai, Mark Cornell Manning, Theodore W. Randolph, and John F. Carpenter, J. Pharm. Sci. 2011, 100: 836-848.

“Product Development Issues with PEGylated Proteins”, Robert W. Payne, Brian M. Murphy, and Mark Cornell Manning, Pharm. Dev. Technol. 2011, 16: 423-440.

“Structure, Stability, and Mobility of a Lyophilized IgG1 Monoclonal Antibody as Determined by Second Derivative Infrared Spectroscopy”, Brian M. Murphy, Ning Zhang, Robert W. Payne, Janice M. Davis, Ahmad M. Abdul-Fattah, James E. Matsuura, Alan C. Herman and Mark Cornell Manning, J. Pharm. Sci. 2012, 101: 81-91.

“Comparability of Protein Therapeutics: Quantitative Comparison of Second Derivative Amide I Infrared Spectra”, Jennifer D’Antonio, Brian M. Murphy, Mark Cornell Manning, and Wasfi A. Al-Azzam, J. Pharm. Sci. 2012, 101: 2025-2033.

“Physical Stability of Albinterferon alfa-2b in Aqueous Solution- Effects of Conformational Stability and Colloidal Stability on Aggregation”, Danny K. Chou, Rajesh Krishnamurthy, Mark Cornell Manning, Theodore W. Randolph, and John F. Carpenter, J. Pharm. Sci. 2012, 101: 2702-2719.

“Characterization of Protein Higher Order Structure using Vibrational Circular Dichroism (VCD) Spectroscopy”, Radhika Nagarkar, Brian M. Murphy, Xiaotong Xu, Mark Cornell Manning, and Wasfi A. Al-Azzam, Curr. Pharm. Biotechnol. 2013, 14: 199-208.

 “Stability of Lyophilized Sucrose Formulations of an IgG1: Subvisible Particle Formation”, Janice M. Davis, Ning Zhang, Robert W. Payne, Brian M. Murphy, Ahmad M. Abdul-Fattah, James E. Matsuura, Alan C. Herman and Mark Cornell Manning, Pharm. Dev. Technol. 2013, in press.

 “Effects of Solution Conditions on Methionine Oxidation in Albinterferon alfa-2b and the Role of Oxidation in its Conformation and Aggregation”, Danny K. Chou, Rajesh Krishnamurthy, Mark Cornell Manning, Theodore W. Randolph, and John F. Carpenter, J. Pharm. Sci. 2013, 102: 660-673.

“Flow Imaging: Moving Towards Best Practices for Subvisible Particle Quantitation in Protein Products”, Glenn A. Wilson and Mark Cornell Manning, J. Pharm. Sci. 2013, 102: 1133-1134.

“Protein Instability during Shipping: Implications for Basic and Applied Research”, Brian M. Murphy, Spencer Swarts, Barbara M. Mueller, Peter van der Geer, Mark Cornell Manning, and Mark Fitchmun, Nature Methods 2013, 10: 278-279.

“Use of the Amide II Infrared Band of Proteins for Secondary Structure Determination and Comparability of Higher Order Structure”, Brian M. Murphy, Jennifer D’Antonio, Mark Cornell Manning, and Wasfi A. Al-Azzam, Curr. Pharm. Biotechnol. 2014, 15(9): 880-889.

“Review of Orthogonal Methods to Size Exclusion Chromatography (SEC) for Quantitation and Characterization of Protein Aggregates”, Ryan R. Manning, Ryan E. Holcomb, Glenn A. Wilson, Charles S. Henry, and Mark Cornell Manning, BioPharm Intl. 2014, 27(11): 32+.

“Comparability of Higher Order Structure in Proteins: Chemometric Analysis of Second Derivative Amide I Fourier Transform Infrared (FTIR) Spectra”, Gregory Stockdale, Brian M. Murphy, Jennifer D’Antonio, Mark Cornell Manning, and Wasfi A. Al-Azzam, J. Pharm. Sci. 2015, 104(1): 25-33.

“Stability of Lyophilized Teriparatide, PTH(1-34) After Reconstitution”, Gene Merutka, Brian M. Murphy, Glenn A. Wilson, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, Eur. J. Pharm. Biopharm. 2016, 99: 84-93.

“Role of Buffers in Protein Formulations”, Teddy J. Zbacnik, Ryan E. Holcomb, Derrick S. Katayama, Brian M. Murphy, Robert W. Payne, Richard C. Coccaro, Gabriel J. Evans, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2017, 106: 713-733.