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Recent Publications

We have published the following articles recently:

“Chemometric Study of the Relative Aggregation Rate of Position 19 Mutants of Ab(1-42)”, Nathaniel J. Zbacnik, Charles S. Henry, and Mark Cornell Manning, Current Protein and Peptide Science 2022, 23: 52-60.

“Characterization of Oligomer Species in Surfactant Protein-D (SP-D) using AF4-MALLS”, Ryan R. Manning, Ryan E. Holcomb, Derrick S. Katayama, Giovanni M. Pauletti, Shawn N. Grant, Jan S. Rosenbaum, and Mark Cornell Manning, Current Protein and Peptide Science 2022, 23: in press.

“Analysis of Peptides using Asymmetrical Flow Field-Flow Fractionation”, Ryan R. Manning, Ryan E. Holcomb, Derrick S. Katayama, Robert W. Payne, Joshua M. Stillahn, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2021, 110: 3969-3972.

“Shape Characterization of Subvisible Particles using Dynamic Imaging Analysis”, Roman Mathaes, Mark Cornell Manning, Gerhard Winter, Ahmed Besheer, Julia Engert, and Glenn A. Wilson, J. Pharm. Sci. 2020109: 375-279.

“A Chemometric Approach towards Predicting the Relative Aggregation Propensity of Amyloidogenic Peptides: Ab(1-42)”, Nathaniel J. Zbacnik, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2020, 109: 624-632.

“High Throughput Detection of Deamidation Using S-(5’-adenosyl)-L-homocysteine Hydrolase and a Fluorogenic Reagent”, Brian M. Murphy, Tarik Ozumerzifon, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Biomed. Analysis 2018156: 323-327.

“Denaturation and Aggregation of Interferon-t in Aqueous Solution”, Ryan R. Manning, Ryan E. Holcomb, Auria A. Tellechea, Chelsey L. Gilley-Dunn, Nathaniel J. Zbacnik, Glenn A. Wilson, Ryan J. Krammes, Nathan S. Krammes, Gabriel J. Evans, Charles S. Henry, Mark Cornell Manning, Brian M. Murphy, Robert W. Payne, and Derrick S. Katayama, Pharm. Res. 201835: article 137.

“Current Status of Analytical Techniques for Characterization of Protein Stability”, Sanket Patke, Joshua M. Stillahn, and Mark Cornell Manning, Biopharma Asia 2018, 6(1): 26+.

“Rational Design of Liquid Formulations of Proteins”, Mark Cornell Manning, Jun Liu, Tiansheng Li, Ryan E. Holcomb, Adv. Protein Chem. Struct. Biol. 2018, 112: 1-59.

“Role of Buffers in Protein Formulations”, Teddy J. Zbacnik, Ryan E. Holcomb, Derrick S. Katayama, Brian M. Murphy, Robert W. Payne, Richard C. Coccaro, Gabriel J. Evans, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2017106: 713-733.

Books recently published which Legacy BioDesign contributed to:
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals
Legacy BioDesign is proud to announce that "Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals" is now published! We have contributed three chapters (see below) to this volume and hope you will find it helpful in your work. For more information or to purchase a copy, visit www.wiley.com or click here.

The chapters are:
"Protein Stability during Bioprocessing" Mark Cornell Manning, Gabriel J. Evans, and Robert W. Payne
Legacy BioDesign LLC, Johnstown, CO 80534-6404 USA
Contact us if you have protein stability issues during processing.

"Prediction of Aggregation Propensity from Primary Sequence Information" Mark Cornell Manning, Gabriel J. Evans,Cody M. Van Pelt, and Robert W. Payne
Legacy BioDesign LLC, Johnstown, CO 80534-6404 USA

"Chemical Instability of Proteins and Peptides", Elizabeth M. Topp1, Lei Zhang1, Hong Zhao1, Robert W. Payne2, Gabriel J. Evans2, and Mark Cornell Manning2

1Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS
2Legacy BioDesign LLC