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Recent Publications

We have published the following articles recently:

“Current Status of Analytical Techniques for Characterization of Protein Stability”, Sanket Patke, Joshua M. Stillahn, and Mark Cornell Manning, Biopharma Asia 2018, 6(1): 26+.

“Rational Design of Liquid Formulations of Proteins”, Mark Cornell Manning, Jun Liu, Tiansheng Li, Ryan E. Holcomb, , Adv. Protein Chem. Struct. Biol. 2018, 112: 1-59.

“Role of Buffers in Protein Formulations”, Teddy J. Zbacnik, Ryan E. Holcomb, Derrick S. Katayama, Brian M. Murphy, Robert W. Payne, Richard C. Coccaro, Gabriel J. Evans, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2017, 106: 713-733.

 “Stability of Lyophilized Teriparatide, PTH(1-34) After Reconstitution”, Gene Merutka, Brian M. Murphy, Glenn A. Wilson, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, Eur. J. Pharm. Biopharm. 2016, 99: 84-93.

“Comparability of Higher Order Structure in Proteins: Chemometric Analysis of Second Derivative Amide I Fourier Transform Infrared (FTIR) Spectra”, Gregory Stockdale, Brian M. Murphy, Jennifer D’Antonio, Mark Cornell Manning, and Wasfi A. Al-Azzam, J. Pharm. Sci. 2015, 104(1): 25-33.

“Use of the Amide II Infrared Band of Proteins for Secondary Structure Determination and Comparability of Higher Order Structure”, Brian M. Murphy, Jennifer D’Antonio, Mark Cornell Manning, and Wasfi A. Al-Azzam, Curr. Pharm. Biotechnol. 2014, 15(9): 880-889.

“Review of Orthogonal Methods to Size Exclusion Chromatography (SEC) for Quantitation and Characterization of Protein Aggregates”, Ryan R. Manning, Ryan E. Holcomb, Glenn A. Wilson, Charles S. Henry, and Mark Cornell Manning, BioPharm Intl. 2014, 27(11): 32+.

“Structural Characteristics of Short Peptides in Solution”, Satoshi Ohtake, Yoshiko Kita, Robert W. Payne, and Mark Cornell Manning, and Tsutomu Arakawa, Protein Peptide Lett. 2013, 20: 1308-1326.

“Protein Instability during Shipping: Implications for Basic and Applied Research”, Brian M. Murphy, Spencer Swarts, Barbara M. Mueller, Peter van der Geer, Mark Cornell Manning, and Mark Fitchmun, Nature Methods 2013, 10: 278-279.

“Flow Imaging: Moving Towards Best Practices for Subvisible Particle Quantitation in Protein Products”, Glenn A. Wilson and Mark Cornell Manning, J. Pharm. Sci. 2013, 102: 1133-1134.

“Effects of Solution Conditions on Methionine Oxidation in Albinterferon alfa-2b and the Role of Oxidation in its Conformation and Aggregation”, Danny K. Chou, Rajesh Krishnamurthy, Mark Cornell Manning, Theodore W. Randolph, and John F. Carpenter, J. Pharm. Sci. 2013, 102: 660-673.

“Characterization of Protein Higher Order Structure using Vibrational Circular Dichroism (VCD) Spectroscopy”, Radhika Nagarkar, Brian M. Murphy, Xiaotong Xu, Mark Cornell Manning, and Wasfi A. Al-Azzam, Curr. Pharm. Biotechnol. 2013, 14: 199-208.

“Stability of Lyophilized Sucrose Formulations of an IgG1: Subvisible Particle Formation”, Janice M. Davis, Ning Zhang, Robert W. Payne, Brian M. Murphy, Ahmad M. Abdul-Fattah, James E. Matsuura, Alan C. Herman and Mark Cornell Manning, Pharm. Dev. Technol. 2013, 18: 883-896.

Books recently published which Legacy BioDesign contributed to:
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals
Legacy BioDesign is proud to announce that "Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals" is now published! We have contributed three chapters (see below) to this volume and hope you will find it helpful in your work. For more information or to purchase a copy, visit www.wiley.com or click here.

The chapters are:
"Protein Stability during Bioprocessing" Mark Cornell Manning, Gabriel J. Evans, and Robert W. Payne
Legacy BioDesign LLC, Johnstown, CO 80534-6404 USA
Contact us if you have protein stability issues during processing.

"Prediction of Aggregation Propensity from Primary Sequence Information" Mark Cornell Manning, Gabriel J. Evans,Cody M. Van Pelt, and Robert W. Payne
Legacy BioDesign LLC, Johnstown, CO 80534-6404 USA

"Chemical Instability of Proteins and Peptides", Elizabeth M. Topp1, Lei Zhang1, Hong Zhao1, Robert W. Payne2, Gabriel J. Evans2, and Mark Cornell Manning2

1Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS
2Legacy BioDesign LLC