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Recent Publications

We have published the following articles recently:

“Role of Buffers in Protein Formulations”, Teddy J. Zbacnik, Ryan E. Holcomb, Derrick S. Katayama, Brian M. Murphy, Robert W. Payne, Richard C. Coccaro, Gabriel J. Evans, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2017, 106: 713-733.

 “Stability of Lyophilized Teriparatide, PTH(1-34) After Reconstitution”, Gene Merutka, Brian M. Murphy, Glenn A. Wilson, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, Eur. J. Pharm. Biopharm. 2016, 99: 84-93.

“Comparability of Higher Order Structure in Proteins: Chemometric Analysis of Second Derivative Amide I Fourier Transform Infrared (FTIR) Spectra”, Gregory Stockdale, Brian M. Murphy, Jennifer D’Antonio, Mark Cornell Manning, and Wasfi A. Al-Azzam, J. Pharm. Sci. 2015, 104(1): 25-33.

“Use of the Amide II Infrared Band of Proteins for Secondary Structure Determination and Comparability of Higher Order Structure”, Brian M. Murphy, Jennifer D’Antonio, Mark Cornell Manning, and Wasfi A. Al-Azzam, Curr. Pharm. Biotechnol. 2014, 15(9): 880-889.

“Review of Orthogonal Methods to Size Exclusion Chromatography (SEC) for Quantitation and Characterization of Protein Aggregates”, Ryan R. Manning, Ryan E. Holcomb, Glenn A. Wilson, Charles S. Henry, and Mark Cornell Manning, BioPharm Intl. 2014, 27(11): 32+.

“Structural Characteristics of Short Peptides in Solution”, Satoshi Ohtake, Yoshiko Kita, Robert W. Payne, and Mark Cornell Manning, and Tsutomu Arakawa, Protein Peptide Lett. 2013, 20: 1308-1326.

“Protein Instability during Shipping: Implications for Basic and Applied Research”, Brian M. Murphy, Spencer Swarts, Barbara M. Mueller, Peter van der Geer, Mark Cornell Manning, and Mark Fitchmun, Nature Methods 2013, 10: 278-279.

“Flow Imaging: Moving Towards Best Practices for Subvisible Particle Quantitation in Protein Products”, Glenn A. Wilson and Mark Cornell Manning, J. Pharm. Sci. 2013, 102: 1133-1134.

“Effects of Solution Conditions on Methionine Oxidation in Albinterferon alfa-2b and the Role of Oxidation in its Conformation and Aggregation”, Danny K. Chou, Rajesh Krishnamurthy, Mark Cornell Manning, Theodore W. Randolph, and John F. Carpenter, J. Pharm. Sci. 2013, 102: 660-673.

“Characterization of Protein Higher Order Structure using Vibrational Circular Dichroism (VCD) Spectroscopy”, Radhika Nagarkar, Brian M. Murphy, Xiaotong Xu, Mark Cornell Manning, and Wasfi A. Al-Azzam, Curr. Pharm. Biotechnol. 2013, 14: 199-208.

“Stability of Lyophilized Sucrose Formulations of an IgG1: Subvisible Particle Formation”, Janice M. Davis, Ning Zhang, Robert W. Payne, Brian M. Murphy, Ahmad M. Abdul-Fattah, James E. Matsuura, Alan C. Herman and Mark Cornell Manning, Pharm. Dev. Technol. 2013, 18: 883-896.

“Comparability of Protein Therapeutics: Quantitative Comparison of Second Derivative Amide I Infrared Spectra”, Jennifer D’Antonio, Brian M. Murphy, Mark Cornell Manning, and Wasfi A. Al-Azzam, J. Pharm. Sci. 2012, 101: 2025-2033.

 “Structure, Stability, and Mobility of a Lyophilized IgG1 Monoclonal Antibody as Determined by Second Derivative Infrared Spectroscopy”, Brian M. Murphy, Ning Zhang, Robert W. Payne, Janice M. Davis, Ahmad M. Abdul-Fattah, James E. Matsuura, Alan C. Herman and Mark Cornell Manning, J. Pharm. Sci. 2012, 101: 81-91.

“Physical Stability of Albinterferon alfa-2b in Aqueous Solution- Effects of Conformational Stability and Colloidal Stability on Aggregation”, Danny K. Chou, Rajesh Krishnamurthy, Mark Cornell Manning, Theodore W. Randolph, and John F. Carpenter, J. Pharm. Sci. 2012, 101: 2702-2719.

“Product Development Issues with PEGylated Proteins”, Robert W. Payne, Brian M. Murphy, and Mark Cornell Manning, Pharm. Dev. Technol. 2011, 16: 423-440.

“Aggregation of Recombinant Human Botulinum Protein Antigen Serotype C in Varying Solution Conditions: Implications of Conformational Stability on Aggregation Kinetics”, Shujun Bai, Mark Cornell Manning, Theodore W. Randolph, and John F. Carpenter, J. Pharm. Sci. 2011, 100: 836-848.

“Culturing and Investigation of Stress-Induced Lipid Accumulation in Microalgae using a Microfluidic Device”, Ryan E. Holcomb, Lucas J. Mason, Kenneth F. Reardon, Donald M. Cropek, and Charles S. Henry, Analytical Bioanalytical Chem. 2011, 400: 245-253.

“Protein Stability during Bioprocessing”, Mark Cornell Manning, Gabriel J. Evans, and Robert W. Payne, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 605-624.

“Chemical Instability in Peptide and Protein Pharmaceuticals”, Elizabeth M. Topp, Lei Zhang, Hong Zhao, Robert W. Payne, Gabriel J. Evans, and Mark Cornell Manning, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 41-67.

“Prediction of Aggregation Propensity from Primary Sequence Information”, Mark Cornell Manning, Gabriel J. Evans, Cody M. Van Pelt, and Robert W. Payne, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 329-347.

“Protein Stability during Bioprocessing”, Mark Cornell Manning, Gabriel J. Evans, and Robert W. Payne, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 605-624.

“Chemical Instability in Peptide and Protein Pharmaceuticals”, Elizabeth M. Topp, Lei Zhang, Hong Zhao, Robert W. Payne, Gabriel J. Evans, and Mark Cornell Manning, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 41-67.

“Stability of Protein Pharmaceuticals: An Update”, Mark Cornell Manning, Danny K. Chou, Brian M. Murphy, Robert W. Payne, and Derrick S. Katayama, Pharm. Res. 2010, 27: 544-575.

“Microfluidic Applications in Metabolomics and Metabolic Profiling”, James R. Kraly, Ryan E. Holcomb, Qian Guan, and Charles S. Henry, Analytica Chim. Acta 2009, 653: 23-35.

“Mixing Properties of Lyophilized Protein Systems: A Spectroscopic and Calorimetric Study”, Derrick S. Katayama, John F. Carpenter, Kevin P. Menard, Mark Cornell Manning, and Theodore W. Randolph, J. Pharm. Sci. 2009, 98: 2954-2969.

“Stability of Human Serum Albumin during Bioprocessing. Aggregation during Terminal Heat Treatment”, Jen-Jen Lin, Jeffrey D. Meyer, John F. Carpenter, and Mark Cornell Manning, Intl. J. Biol. Macromol. 2009, 45: 91-96.

“Impact of Bulking Agents on the Stability of a Lyophilized Monoclonal Antibody”, Jeffrey D. Meyer, Rajiv Nayar, and Mark Cornell Manning, Eur. J. Pharm. Sci. 2009, 38: 29-38.

“Ability of Two All Natural Products, Nootkatone and Carvacrol, to Supress Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) in a Lyme Disease Endemic Area of New Jersey”, Marc C. Dolan, Robert A. Jordan, Terry L. Schulze, Christopher J. Schulze, Mark Cornell Manning, Daniel Ruffolo, Jason P. Schmidt, Joseph Piesman, and Joseph J. Karchesy, J. Econ. Entomol. 2009, 102: 2316-2324.

“Peptide Formulation: Challenges and Strategies”, Robert W. Payne and Mark Cornell Manning, Innov. Pharm. Technol. Spring 2009, 28: 64-68.

“Multivariate Analysis of the Sequence Dependence of Asparagine Deamidation Rates in Peptides”, Andrew A. Kosky, Vasumathi Dharmavaram, Gayathri Ratnaswamy, and Mark Cornell Manning, Pharmaceutical Res. 2009, 26: 2417-2428.

“Electrode Array Detector for Microchip Capillary Electrophoresis”, Ryan E. Holcomb, James R. Kraly, and Charles S. Henry, Analyst 2009, 134: 486-492.

”Microfluidic Applications in Metabolomics and Metabolic Profiling”, James R. Kraly, Ryan E. Holcomb, Qian Guan, and Charles S. Henry, Analytica Chim. Acta 2009, 653: 23-35.

“Analysis of Oxidative Stress Biomarkers using a Simultaneous Competitive/Non-Competitive Micromosaic Immunoassay”, Brian M. Murphy, David S. Dandy, and Charles S. Henry, Analytica Chim. Acta 2009, 640: 1-6.

Tools to Enhance Membrane Protein Crystallization”, W. William Wilson, Gregg Whited, Robert W. Payne, Charles Henry, David H. Johnson, and Larry DeLucas, Current Topics in Membranes 2009, 63: 151-178.


Books recently published which Legacy BioDesign contributed to:
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals
Legacy BioDesign is proud to announce that "Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals" is now published! We have contributed three chapters (see below) to this volume and hope you will find it helpful in your work. For more information or to purchase a copy, visit www.wiley.com or click here.

The chapters are:
"Protein Stability during Bioprocessing" Mark Cornell Manning, Gabriel J. Evans, and Robert W. Payne
Legacy BioDesign LLC, Johnstown, CO 80534-6404 USA
Contact us if you have protein stability issues during processing.

"Prediction of Aggregation Propensity from Primary Sequence Information" Mark Cornell Manning, Gabriel J. Evans,Cody M. Van Pelt, and Robert W. Payne
Legacy BioDesign LLC, Johnstown, CO 80534-6404 USA

"Chemical Instability of Proteins and Peptides", Elizabeth M. Topp1, Lei Zhang1, Hong Zhao1, Robert W. Payne2, Gabriel J. Evans2, and Mark Cornell Manning2

1Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS
2Legacy BioDesign LLC