PROTEIN STABILITY DURING BIOPROCESSING

Another area where Legacy has some unique expertise is in identifying protein instabilities during processing. Using multivariate statistical methods (such as Principal Component Analysis and Projection to Latent Structures), we are able to determine the potential source of the damage to the protein. Then an efficient strategy for diminishing or retarding protein degradation can be developed and implemented. We are able to design and conduct studies on the potential adverse effects of shear, agitation, filtration and other stresses. Beginning in 2007, there will be a presentation on this topic in the three-day short course we present on peptide and protein stabilization and formulation, offered through the European Continuing Education College.