Recent Publications

All of the Legacy’s scientific staff also have appointments at Colorado State University (CSU). Consequently, each of our publication acknowledges our connection to CSU as well as Legacy BioDesign.

Recently Published Articles:

“Application of Formulation Principles to Stability Issues Encountered during Analysis, Processing and Manufacturing of Drug Substance and Drug Product Protein Therapeutics”, Samadhi Vitharana, Joshua M. Stillahn, Derrick S. Katayama, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2023, 112: 2724-2751.

“Chemometric Study of the Relative Aggregation Rate of Position 19 Mutants of Aβ(1-42)”, Nathaniel J. Zbacnik, Charles S. Henry, and Mark Cornell Manning, Current Protein and Peptide Science 2022, 23: 52-60.

“Characterization of Oligomer Species in Surfactant Protein-D (SP-D) using AF4-MALLS”, Ryan R. Manning, Ryan E. Holcomb, Derrick S. Katayama, Giovanni M. Pauletti, Shawn N. Grant, Jan S. Rosenbaum, and Mark Cornell Manning, Current Protein and Peptide Science 2022, 23: 862-873.

“Analysis of Peptides using Asymmetrical Flow Field-Flow Fractionation”, Ryan R. Manning, Ryan E. Holcomb, Derrick S. Katayama, Robert W. Payne, Joshua M. Stillahn, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2021, 110: 3969-3972.

“Shape Characterization of Subvisible Particles using Dynamic Imaging Analysis”, Roman Mathaes, Mark Cornell Manning, Gerhard Winter, Ahmed Besheer, Julia Engert, and Glenn A. Wilson, J. Pharm. Sci. 2020, 109: 375-279.

“A Chemometric Approach towards Predicting the Relative Aggregation Propensity of Amyloidogenic Peptides: Aβ(1-42)”, Nathaniel J. Zbacnik, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2020, 109: 624-632.

“High Throughput Detection of Deamidation Using S-(5’-adenosyl)-L-homocysteine Hydrolase and a Fluorogenic Reagent”, Brian M. Murphy, Tarik Ozumerzifon, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Biomed. Analysis 2018, 156: 323-327.

“Denaturation and Aggregation of Interferon-τ in Aqueous Solution”, Ryan R. Manning, Ryan E. Holcomb, Auria A. Tellechea, Chelsey L. Gilley-Dunn, Nathaniel J. Zbacnik, Glenn A. Wilson, Ryan J. Krammes, Nathan S. Krammes, Gabriel J. Evans, Charles S. Henry, Mark Cornell Manning, Brian M. Murphy, Robert W. Payne, and Derrick S. Katayama, Pharm. Res. 2018, 35: article 137.

“Current Status of Analytical Techniques for Characterization of Protein Stability”, Sanket Patke, Joshua M. Stillahn, and Mark Cornell Manning, Biopharma Asia 2018, 6(1): 26+.

“Rational Design of Liquid Formulations of Proteins”, Mark Cornell Manning, Jun Liu, Tiansheng Li, Ryan E. Holcomb, Adv. Protein Chem. Struct. Biol. 2018, 112: 1-59.

“Role of Buffers in Protein Formulations”, Teddy J. Zbacnik, Ryan E. Holcomb, Derrick S. Katayama, Brian M. Murphy, Robert W. Payne, Richard C. Coccaro, Gabriel J. Evans, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2017, 106: 713-733.